Canine Melanocytic Tumor Synoptic Report Please enable JavaScript in your browser to complete this form.This report generator should be used with caution by the pathologist - always verify information produced by this tool. NOTE: Additional questions may be revealed by the answers to other questions (i.e., tumor margins are not asked unless tumor is listed as "not present" at margins). NOTE: This only generates a synoptic report. This may not represent a full pathology report. Sample Measurements (cm) (gross - post fixation)Maximum Tumor Dimension (cm) (gross - post fixation)The largest dimension of the tumor measured at the time of trimming (post fixation)Sample inked?Yes, by submitterYes, by laboratoryNo (representative sections)Method of TrimmingSingle SectionPerpendicular sections (cross section and lateral margins)Serial sections (e.g., bread loafing)Number of sections examinedWas sample bleached?YesNoMarginsSee the Margin Evaluation Guideline for more information.Neoplasia at Margin?PresentAbsentHistologic Tumor Free Distance - Deep (mm)Histologic Tumor Free Distance - Peripheral (mm)Lentiginous SpreadPresentAbsentCannot determine (e.g. due to diffuse ulceration and/or lack of lateral flanking epithelium in the received specimen)Lateral spread within the epidermisLymphovascular InvasionSee the Lymphovascular Invasion Guideline for more information.Lymphovascular InvasionNot identifiedEquivocalPresentLymphovascular Invasion Criteria DetectedThrombus adherent to intravascular tumorTumor cells invading through a vessel wall and endotheliumNeoplastic cells within a space lined by lymphatic or blood vascular endotheliumNeoplastic cells in a structure confirmed to be a lymphatic or blood vessel by the use of IHC markersNucleiNuclear Atypia<20%≥20%See the Canine Cutaneous Melanocytic Neoplasms Protocol for more informationMitotic CountSee the Mitotic Count Guideline for more information.Mitotic Count per 2.37mm2DifferentiationTumor thickness (mm)Measured by applying a ruler perpendicularly to the epidermis and measuring the greatest thickness of the tumor. This can be measured on WSI also.Histologic assessment of pigmentation<50% of cells pigmented≥50% of cells pigmentedDiffuse heavy pigmentation – visualization of cellular morphology is histologically difficultOptional InformationKi67 - % immunoreactive melanocyte nuclei<15%≥15%See Laprie et al. MIB-1 immunoreactivity correlates with biologic behaviour in canine cutaneous melanoma. Vet Dermatol. 2001;12: 139-147 for more information. Avoid areas of ulceration, necrosis, and inflammation and do not count intraepithelial neoplastic cells. Count in highest labeling area. Were any lymph nodes submitted?YesNoSpecify lymph nodes submitted (if specified)Total number of lymph node sections evaluatedWere metastases detected in lymph nodes?YesNoEquivocalLymph node sections with metastasesHistologic TypeMelanomaMelanocytomaMelanocytic neoplasmLocation of neoplastic cellsEpidermal onlyDermal onlyCompound – has both epidermal and dermal componentsPredominant cell typeEpithelioid/polygonalSpindloid/fibromatousMixed epithelioid and spindloidRound cellSmall cellBalloon/clear/signet-ring cellGiant cellRhabdoidMyxoidOtherWhorled/dendriticAdenomatous/papillaryOsteocartilaginous differentiationAngiotropic or angiomatoid (pseudovascular)Submit